Glutathione 600mg — GSH master antioxidant, redox & radiance

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600mg vialIncluded
Bacteriostatic waterAdd
1 ml syringesAdd

The vial alone cannot be used as is. One sealed vial of Glutathione 600mg, lyophilised, without individual labelling.

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Eau Bactériostatique

7,90 €

Seringue de précision 1ml 29Gx107,90 €

Lingettes alcool isopropylique 70%x103,90 €

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Glutathione 600mg (GSH, reduced L-glutathione) is the master antioxidant tripeptide of the living cell, with the sequence gamma-Glu-Cys-Gly. Its structural feature is unique among peptides: the gamma bond, formed via the glutamate side chain, makes it resistant to classical peptidases and explains its biological stability. With a molecular weight of 307 Da and the formula C10H17N3O6S, glutathione is present in every cell at millimolar concentrations, where it forms the first line of defense against oxidative stress.

This 600mg format is a premium dosing, calibrated for high molar-load research protocols (oxidative stress models, hepatic detoxification studies, skin depigmentation research). The high mass per vial avoids multiplying units for consuming protocols, while guaranteeing a single HPLC >98% controlled batch.

At the heart of longevity and skin beauty research, glutathione concentrates three roles: free radical neutralization, cellular detoxification and skin radiance through melanogenesis modulation. It is the reference molecule for studying redox balance and the oxidative protection of tissues.

Science

01
Mechanism of action

Glutathione's mechanism of action relies on the sulfur chemistry of its central cysteine, whose thiol group (-SH) is the true active site.

Direct neutralization of reactive species. The cysteine thiol donates an electron to neutralize free radicals (ROS, reactive oxygen species). Two molecules of reduced glutathione (GSH) then oxidize into glutathione disulfide (GSSG). The GSH/GSSG ratio is the reference indicator of cellular redox state in research, subsequently restored by glutathione reductase using NADPH.

Cofactor of glutathione peroxidases. GSH fuels the glutathione peroxidase enzymes that destroy hydrogen peroxide and lipid peroxides, protecting membranes from peroxidation. It is a pillar of enzymatic antioxidant defense.

Phase II detoxification. Via glutathione-S-transferases, GSH conjugates with xenobiotics, heavy metals and electrophilic metabolites, making them water-soluble and eliminable (mercapturic acid pathway). This is the central mechanism of cellular detoxification studied in hepatic models.

Skin radiance and melanogenesis. Glutathione inhibits tyrosinase and shifts melanin synthesis toward light pheomelanin rather than dark eumelanin. This mechanism founds research on skin depigmentation and radiance, the field where glutathione is the most studied candidate.

Clinical data

02Clinical studies

Glutathione is one of the most studied antioxidants in biology, with a corpus spanning several decades.

Redox balance and oxidative stress. The GSH/GSSG ratio is a validated oxidative-stress marker in countless cellular and animal models. Glutathione depletion sensitizes cells to oxidative apoptosis, a repeated demonstration of its fundamental protective role.

Hepatic detoxification. The liver is the organ richest in glutathione. Toxicity models (notably acetaminophen overdose, where N-acetylcysteine restores glutathione) established GSH's central role in neutralizing reactive metabolites.

Skin depigmentation. Several clinical trials, especially in Asian dermatology, evaluated glutathione (oral, topical and intravenous) on skin radiance and lightness, with positive results but methodological heterogeneity and an ongoing debate on the optimal administration route and effect duration.

Bioavailability and forms. The literature widely documents the poor oral bioavailability of native glutathione (digestive degradation), which steered research toward injectable, liposomal forms and precursors such as NAC. This delivery question remains an active research axis.

These data position glutathione as a leading redox research tool. Atlas Lab Glutathione 600mg is sold strictly for that purpose, without therapeutic or cosmetic status.

No references yet for this peptide — search PubMed for associated scientific literature.

The listed studies are provided for documentation and research purposes only. They do not constitute a therapeutic indication nor a recommendation for human use. This product is strictly for laboratory use only (RUO).

Lab workflow

03
Research protocols

The Atlas Lab Glutathione 600mg vial is reconstituted with bacteriostatic water or saline. The high mass requires a larger solvent volume than micro-dose peptides: 6 ml gives a concentration of 100 mg/ml, 3 ml gives 200 mg/ml. Glutathione is highly soluble in aqueous medium; the resulting solution is slightly acidic, which is normal for this tripeptide.

Reference schemes. Injectable glutathione research protocols classically use doses between 600 and 1200 mg per administration in depigmentation and oxidative-stress models, often in closely spaced series. The intravenous route is the literature reference due to poor oral bioavailability. Fractioning and frequency depend strictly on the model studied.

Handling and oxidation. Critical point: glutathione's thiol group oxidizes in air. Reconstitute just before use, limit exposure to air and light, do not vortex, draw under aseptic conditions. A solution that yellows or clouds signals advanced oxidation (conversion to GSSG) and must be discarded.

Parameters provided for in vitro and model research documentation. For research use only (RUO), no human, cosmetic, diagnostic or therapeutic use.

Reconstitution for this format (600 mg)Standard volumes used in laboratory settings

Water added	Concentration	Reading marker
2 ml	300 mg/ml	10 UI = 30 mg
3 ml	200 mg/ml	10 UI = 20 mg

The volume of water does not change the product, only its concentration. Introduce the water slowly along the vial wall, never directly onto the lyophilisate, then swirl without shaking. Markers given on a 1 ml syringe graduated in 100 units.

Asepsis

Disinfect surfaces and stoppers (70% alcohol).

Solvent

Draw the required volume of bacteriostatic water.

Introduction

Inject gently against the vial wall (avoid direct jet on powder).

Solubilization

Roll the vial gently. Do not shake vigorously (degradation risk).

Solution storageOnce reconstituted: 2-8°C (refrigerator).

WarningTheoretical tool for chemical handling. Does not constitute medical advice.

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What is normal on arrivalThe observations that worry customers, and are not defects

The amount of powder looks tiny. A lyophilisate takes up a few millimetres at the bottom of the vial, sometimes just a translucent film. The stated weight is there.
The powder is compact, stuck to the wall or to the stopper. Transport moves the freeze-dried cake around. It changes nothing to reconstitution.
The vial carries no individual label. That is our standard packaging, not a downgraded vial.
After reconstitution, deposits or filaments appear. This is common, especially with small molecules. Let it settle and roll the vial between your palms, never shake it.
The parcel is plain. Nothing on the outside indicates the contents or the brand name.

What is not normal: a cracked vial, an uncrimped cap or a stopper that moves, powder that has liquefied or changed colour. In those specific cases, write to us with a photo and we take the vial back.

Handling

04Storage & handling

In lyophilized form, Glutathione 600mg is stable when stored at -20°C, away from light and air. The dry powder withstands room-temperature transport over a few days, but since glutathione is oxidation-sensitive, cold storage on receipt is recommended to preserve the maximum reduced form (GSH).

After reconstitution, glutathione is markedly more fragile than most peptides: the solution must be kept at +2/+8°C, away from light, and used quickly (ideally within a few days). Prolonged contact with atmospheric oxygen progressively converts GSH into inactive GSSG. Reseal tightly, minimize the dead air volume in the vial, and avoid any freeze/thaw cycle.

Each Atlas Lab batch is HPLC-tested at over 98% purity, vacuum lyophilized.

01Is glutathione a peptide?

Yes, it is a **tripeptide** (gamma-Glu-Cys-Gly), but atypical: its gamma bond, formed via the glutamate side chain, makes it resistant to classical peptidases. It does not act as a signaling peptide on a receptor, but as the intracellular **master antioxidant** via its cysteine thiol.

02How much solvent to reconstitute the 600mg vial?

Since the mass is high, plan for more volume: **6 ml** of bacteriostatic water gives 100 mg/ml, **3 ml** gives 200 mg/ml. Glutathione is highly soluble; the solution is slightly acidic, which is normal. Reconstitute just before use because the thiol oxidizes in air.

03Why does glutathione oxidize so fast once reconstituted?

Because its **thiol group (-SH)**, the active site, easily donates electrons: in contact with atmospheric oxygen, reduced glutathione (GSH) turns into inactive glutathione disulfide (GSSG). Hence the precautions: reconstitute just before use, away from air and light, keep cold and use quickly. A yellowing solution must be discarded.

04Why a 600mg format, higher dosed than classic peptides?

Because glutathione is studied at **high molar load**: redox and depigmentation research protocols classically use 600 to 1200 mg per administration, far from the micro-doses of signaling peptides. The 600mg format covers these protocols from a single controlled batch.

05What is the difference between glutathione and NAC?

**NAC (N-acetylcysteine)** is a **precursor**: it supplies the limiting cysteine so the cell makes its own glutathione. **Glutathione 600mg** directly provides the whole, active molecule. Precursor approach versus direct approach, depending on the research model.

06Can Atlas Lab Glutathione be used in cosmetics or on skin?

No. Although glutathione is studied in skin-radiance research, Atlas Lab Glutathione 600mg is strictly a **research reagent (RUO)**, intended for in vitro and model studies. It has no cosmetic, therapeutic or human status.

Benchmark

Similar peptides

Glutathione vs NAD+. Two pillars of cellular metabolism with distinct roles: glutathione manages redox balance and detoxification (thiol chemistry), NAD+ manages energy metabolism and sirtuins (mitochondrial electron transfer). Complementary in any aging-biology approach.

Glutathione vs GHK-Cu. In skin research, glutathione acts on radiance and depigmentation (tyrosinase inhibition, antioxidation); GHK-Cu acts on matrix regeneration (collagen, elastin, over 4000 genes). Two different skin levers, often studied in parallel.

Glutathione vs vitamin C. Classic synergy: vitamin C regenerates oxidized glutathione and vice versa. Glutathione is the master intracellular antioxidant, vitamin C acts more in the extracellular compartment. The antioxidant network works as a relay.

Glutathione vs NAC (N-acetylcysteine). NAC is a precursor that supplies the limiting cysteine so the cell synthesizes its own glutathione; glutathione 600mg directly provides the whole molecule. Direct approach versus precursor approach, depending on the targeted research model.

Glutathione 600mg Skin & Beauty

Skin Tissues

01
Mechanism of action

02Clinical studies

03
Research protocols

Asepsis

Solvent

Introduction

Solubilization

04Storage & handling

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Skin Tissues

Product information

Asepsis

Solvent

Introduction

Solubilization

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